AP5dT
P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt
Catálogo Nº | Apresentação | Preço (R$) | Comprar |
---|---|---|---|
NU-502S | 50 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
NU-502L | 5 x 50 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C20H30N7O23P5 (free acid)
Peso molecular: 891.36 g/mol (free acid)
CAS#: 103137-88-8
Pureza: ≥ 95 % (HPLC)
Forma: solution in water
Concentração: 10 mM - 11 mM
pH: 7.5 ±0.5
Propriedades espectroscópicas: λmax 262 nm, ε 22.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Referências selecionadas:
Haouz et al. (2003) Enzymatic and Structural Analysis of Inhibitors Designed against Mycobacterium tuberculosis Thymidylate Kinase. J. Biol. Chem. 278 (7):4963.
Lavie et al. (1998) Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proc. Natl. Acad. Sci. USA 95 (24):14045.
Lavie et al. (1998) Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P-1- (5'-adenosyl) P-5- (5'-thymidyl) pentaphosphate (TP (5)A) at 2.0 angstrom resolution: Implications for catalysis and AZT activation. Biochemistry 37:3677.