8-Bromo-GTP
(8Br-GTP)
8-Bromo-guanosine-5'-triphosphate, Sodium salt
Catálogo Nº | Apresentação | Preço (R$) | Comprar |
---|---|---|---|
NU-118S | 50 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
NU-118L | 5 x 50 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C10H15N5O14P3Br (free acid)
Peso molecular: 602.08 g/mol (free acid)
CAS#: 23197-98-0
Pureza: ≥ 95 % (HPLC)
Forma: solution in water
Concentração: 10 mM - 11 mM
pH: 7.5 ±0.5
Propriedades espectroscópicas: λmax 259 nm, ε 14.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Formulários:
Inhibition of RNA triphosphatases[1]
Inhibition of GTP-hydrolases[2]
Conformational studies on syn-anti dynamics of GTP[3]
Specific Ligands:
Yeast RNA triphosphates[1]
Cytoskeletal protein FtsZ and tubulin[2, 4]
Referências selecionadas:
[1] Issur et al. (2009) Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase. Nucleic Acid Res. 37:3714.
[2] Läppchen et al. (2005) GTP Analogue Inhibits Polymerization and GTPase Activity of the Bacterial Protein FtsZ without Affecting Its Eukaryotic Homologue Tubulin. Biochemistry 44 (21):7879.
[3] Hritz and Oostenbrink (2008) Hamiltonian replica exchange molecular dynamics using soft-core interactions. J. Chemical Phys. 128:144121/1.
[4] Laeppchen et al. (2008) Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. Chemistry and Biology 15:189.
Gilles Labesse et al. (2011) Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation. Nucleic Acids Res. 39 (8):3458.